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Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Ji, Xuemei (author)
Dartmouth College
Bosse, Yohan (author)
Landi, Maria Teresa (author)
show more...
Gui, Jiang (author)
Xiao, Xiangjun (author)
Qian, David (author)
Joubert, Philippe (author)
Lamontagne, Maxime (author)
Li, Yafang (author)
Gorlov, Ivan (author)
de Biasi, Mariella (author)
Han, Younghun (author)
Gorlova, Olga (author)
Hung, Rayjean J. (author)
Wu, Xifeng (author)
Mckay, James (author)
Zong, Xuchen (author)
Carreras-Torres, Robert (author)
Christiani, David C. (author)
Caporaso, Neil (author)
Johansson, Mattias (author)
Liu, Geoffrey (author)
Bojesen, Stig E. (author)
Le Marchand, Loic (author)
Albanes, Demetrios (author)
Bickeboeller, Heike (author)
Aldrich, Melinda C. (author)
Bush, William S. (author)
Tardon, Adonina (author)
Rennert, Gad (author)
Chen, Chu (author)
Teare, M. Dawn (author)
Field, John K. (author)
Kiemeney, Lambertus A. (author)
Lazarus, Philip (author)
Haugen, Aage (author)
Lam, Stephen (author)
Schabath, Matthew B. (author)
Andrew, Angeline S. (author)
Shen, Hongbing (author)
Hong, Yun-Chul (author)
Yuan, Jian-Min (author)
Bertazzi, Pier A. (author)
Pesatori, Angela C. (author)
Ye, Yuanqing (author)
Diao, Nancy (author)
Su, Li (author)
Zhang, Ruyang (author)
Brhane, Yonathan (author)
Leighl, Natasha (author)
Johansen, Jakob S. (author)
Mellemgaard, Anders (author)
Saliba, Walid (author)
Haiman, Christopher (author)
Wilkens, Lynne (author)
Fernandez-Somoano, Ana (author)
Fernandez-Tardon, Guillermo (author)
van der Heijden, Erik H. F. M. (author)
Kim, Jin Hee (author)
Dai, Juncheng (author)
Hu, Zhibin (author)
Davies, Michael P. A. (author)
Marcus, Michael W. (author)
Brunnström, Hans (author)
Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups
Manjer, Jonas (author)
Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
Melander, Olle (author)
Lund University,Lunds universitet
Muller, David C. (author)
Overvad, Kim (author)
Lund University
Trichopoulou, Antonia (author)
Tumino, Rosario (author)
Doherty, Jennifer (author)
Goodman, Gary E. (author)
Cox, Angela (author)
Taylor, Fiona (author)
Woll, Penella (author)
Brueske, Irene (author)
Manz, Judith (author)
Muley, Thomas (author)
Risch, Angela (author)
Rosenberger, Albert (author)
Grankvist, Kjell (author)
Umeå universitet,Klinisk kemi
Johansson, Mikael (author)
Umeå universitet,Onkologi
Shepherd, Frances (author)
Tsao, Ming-Sound (author)
Arnold, Susanne M. (author)
Haura, Eric B. (author)
Bolca, Ciprian (author)
Holcatova, Ivana (author)
Janout, Vladimir (author)
Kontic, Milica (author)
Lissowska, Jolanta (author)
Mukeria, Anush (author)
Ognjanovic, Simona (author)
Orlowski, Tadeusz M. (author)
Scelo, Ghislaine (author)
Swiatkowska, Beata (author)
Zaridze, David (author)
Bakke, Per (author)
Skaug, Vidar (author)
Zienolddiny, Shanbeh (author)
Duell, Eric J. (author)
Butler, Lesley M. (author)
Koh, Woon-Puay (author)
Gao, Yu-Tang (author)
Houlston, Richard (author)
McLaughlin, John (author)
Stevens, Victoria (author)
Nickle, David C. (author)
Obeidat, Ma'en (author)
Timens, Wim (author)
Zhu, Bin (author)
Song, Lei (author)
Artigas, Maria Soler (author)
Tobin, Martin D. (author)
Wain, Louise V. (author)
Gu, Fangyi (author)
Byun, Jinyoung (author)
Kamal, Ahsan (author)
Zhu, Dakai (author)
Tyndale, Rachel F. (author)
Wei, Wei-Qi (author)
Chanock, Stephen (author)
Brennan, Paul (author)
Amos, Christopher I. (author)
Dartmouth College
show less...
 (creator_code:org_t)
et al 
2018-08-13
2018
English.
In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9, s. 1-15
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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By the author/editor
Ji, Xuemei
Bosse, Yohan
Landi, Maria Ter ...
Gui, Jiang
Xiao, Xiangjun
Qian, David
show more...
Joubert, Philipp ...
Lamontagne, Maxi ...
Li, Yafang
Gorlov, Ivan
de Biasi, Mariel ...
Han, Younghun
Gorlova, Olga
Hung, Rayjean J.
Wu, Xifeng
Mckay, James
Zong, Xuchen
Carreras-Torres, ...
Christiani, Davi ...
Caporaso, Neil
Johansson, Matti ...
Liu, Geoffrey
Bojesen, Stig E.
Le Marchand, Loi ...
Albanes, Demetri ...
Bickeboeller, He ...
Aldrich, Melinda ...
Bush, William S.
Tardon, Adonina
Rennert, Gad
Chen, Chu
Teare, M. Dawn
Field, John K.
Kiemeney, Lamber ...
Lazarus, Philip
Haugen, Aage
Lam, Stephen
Schabath, Matthe ...
Andrew, Angeline ...
Shen, Hongbing
Hong, Yun-Chul
Yuan, Jian-Min
Bertazzi, Pier A ...
Pesatori, Angela ...
Ye, Yuanqing
Diao, Nancy
Su, Li
Zhang, Ruyang
Brhane, Yonathan
Leighl, Natasha
Johansen, Jakob ...
Mellemgaard, And ...
Saliba, Walid
Haiman, Christop ...
Wilkens, Lynne
Fernandez-Somoan ...
Fernandez-Tardon ...
van der Heijden, ...
Kim, Jin Hee
Dai, Juncheng
Hu, Zhibin
Davies, Michael ...
Marcus, Michael ...
Brunnström, Hans
Manjer, Jonas
Melander, Olle
Muller, David C.
Overvad, Kim
Trichopoulou, An ...
Tumino, Rosario
Doherty, Jennife ...
Goodman, Gary E.
Cox, Angela
Taylor, Fiona
Woll, Penella
Brueske, Irene
Manz, Judith
Muley, Thomas
Risch, Angela
Rosenberger, Alb ...
Grankvist, Kjell
Johansson, Mikae ...
Shepherd, France ...
Tsao, Ming-Sound
Arnold, Susanne ...
Haura, Eric B.
Bolca, Ciprian
Holcatova, Ivana
Janout, Vladimir
Kontic, Milica
Lissowska, Jolan ...
Mukeria, Anush
Ognjanovic, Simo ...
Orlowski, Tadeus ...
Scelo, Ghislaine
Swiatkowska, Bea ...
Zaridze, David
Bakke, Per
Skaug, Vidar
Zienolddiny, Sha ...
Duell, Eric J.
Butler, Lesley M ...
Koh, Woon-Puay
Gao, Yu-Tang
Houlston, Richar ...
McLaughlin, John
Stevens, Victori ...
Nickle, David C.
Obeidat, Ma'en
Timens, Wim
Zhu, Bin
Song, Lei
Artigas, Maria S ...
Tobin, Martin D.
Wain, Louise V.
Gu, Fangyi
Byun, Jinyoung
Kamal, Ahsan
Zhu, Dakai
Tyndale, Rachel ...
Wei, Wei-Qi
Chanock, Stephen
Brennan, Paul
Amos, Christophe ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
Articles in the publication
Nature Communica ...
By the university
Umeå University
Lund University

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